ASHOK KUMAR SATAPATHY
SCIENTIST F

  ASHOK KUMAR SATAPATHY

Publications

Date of Joining Present Post: 01-09-2015

Address (Off):

REGIONAL MEDICAL RESEARCH CENTRE
CHANDRASEKHARPUR
BHUBANESWAR - 751023 .
Telephone (off): 0674-2301399
Fax : 0674-2301351
Email : balaravi@sancharnet.in
Educational Qualifications:

  • Ph.D.
  • M.Sc.

  • Discipline:
    ZOOLOGY



    Research Experience:
    Eight inflammatory and non-inflammatory host molecules in circulation were quantified in 207 subjects in filariasis endemic area of Orissa, India. Found that elevated levels of inflammatory cytokines IL-6, Il-8 and TNF are associated with filarial disease manifestation. Further, this study indicated that the two forms of chronic filarial diseases (Hydrocele and Elephantiasis) significantly different from each other when the ratio of TNFR-I and TNFR-II were analysed. This finding leads us to investigate the polymorphisms of TNFR-I and TNFR-II genes for their association with development of chronic manifestations. Mutation frequency of TNFR-II (M196R) was significantly more in patients with hydrocele in comparison to endemic controls and elephantiasis cases. Demonstrating that genetic Polymorphism of Endothelin-1 and TNF receptor II associated with development of hydrocele and elephantiasis respectively in human lymphatic filariasis. An association between polymorphism of host genes with development of one or the other forms of chronic disease in human lymphatic filariasis has been demonstrated. Antibodies to filarial antigens of different developmental stage have been presumed to be responsible for functional immunity in human filariasis. A significant inverse association has been observed between anti-sheath antibodies and microfilaraemia in Brugian and Bancroftianfilariasis. Compared with other clinical categories of filariasis, microfilariae carriers were deficient in total as well as filarial-specific IgA. More crucially, significantly high levels were observed in putatively immune control subjects from areas of endemicity. The study demonstrates, for the first time, a positive correlation between protective immunity and increased levels of filaria-specific IgA in human bancroftianfilariasis.The profile of B-1 cells from the total B cells by flow cytometry and its association with polyreactive antibodies in filarial infected human population is being investigated. Maternal infection has been considered to be a risk factor for filarial infection in offspring. Our studied demonstrated the influence ofmaternal infection in the cord blood samples of offspringborn from infected mothers living in an areaendemic for bancroftianfilariasis.We investigated to which extent maternal filarial infections have sensitized or biased immune responsiveness in neonates toward a Th1 or Th2-like phenotype. Increased levels of IL-10 (Th-2) and down regulation of IFN- (Th-1) have been detected in cord blood of children born to filarial infected mothers.
    Membership/Fellowship of Professional Societies/Associations :
    1. Member of Indian Immunology Society
    2. Member of National Academy of Vectors and Vector Borne Diseases
    Workshops/Conferences/Symposiums :

    1.Attended a training program on accreditation of laboratories at IIQM, Jaipur from 26th -29th March 2012
    2.Attended 8th joint Annual conference of The Indian Society for malaria and other Communicable Diseases and The Indian association of Epidemiologist held at Bhubaneswar from 15-17April
    3.Attended CPCSEA Regional Workshop on Role of CPCSEA in Education and Research held at Central Glass and Ceramic Research Institute, Kolkatta on 19th April 2010.
    4.Presented paper entitled Polymorphism of Endothelin-1 (Ala288Ser) gene associated with development of hydrocele in lymphatic filariaisis

    A recognized Guide for Ph.D degree by the Utkal University, Bhubaneswar

    Foreign Visits:
    1. TO VISIT IN LABORATORY OF DR. M. YAZDANBAKSH UNIV OF LEIDEN. TO THE NETHERLANDS
      FROM 2002-09-23 TO 2002-10-22


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